Is it clinically defensible to treat children longer term with second generation antipsychotics?
نویسندگان
چکیده
منابع مشابه
Clinically relevant interactions between newer antidepressants and second-generation antipsychotics.
INTRODUCTION Combinations of newer antidepressants and second-generation antipsychotics (SGAs) are frequently used by clinicians. Pharmacokinetic drug interaction (PK DI) and poorly understood pharmacodynamic (PD) drug interaction (PD DI) can occur between them. AREAS COVERED This paper comprehensively reviews PD DI and PK DI studies. EXPERT OPINION More PK DI studies are needed to better e...
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Background: The use of second-generation antipsychotic (SGA) medication among child and adolescent psychiatric patients has increased worldwide in recent years. The increase appears to have been more extensive in the USA than in European countries, but the tendency is similar. However, after a peak the use seems to have declined in the USA. Simultaneously with the increasing numbers, the durati...
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The emergence of the Leapfrog group initiative to use measures of quality and safety as criteria for contracting for provision of medical services was a watershed event. Major payers would pay for quality, or, more accurately, no longer pay for inferior quality. Not surprisingly, physicians have been skeptical about this enterprise. Battered over the past 2 decades by an never-ending array of p...
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INTRODUCTION Pharmacokinetic and pharmacodynamic drug interactions (DIs) can occur between antiepileptics (AEDs) and second-generation antipsychotics (SGAPs). Some AED and SGAP pharmacodynamic mechanisms are poorly understood. AED-SGAP combinations are used for treating comorbid illnesses or increasing efficacy, particularly in bipolar disorder. AREAS COVERED This article provides a comprehen...
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Antipsychotic-induced extrapyramidal adverse effects are well recognized in the context of first-generation antipsychotic drugs. However, the introduction of second-generation antipsychotics, with atypical mechanism of action, especially lower dopamine receptors affinity, was met with great expectations among clinicians regarding their potentially lower propensity to cause extrapyramidal syndro...
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ژورنال
عنوان ژورنال: Expert Opinion on Drug Safety
سال: 2018
ISSN: 1474-0338,1744-764X
DOI: 10.1080/14740338.2018.1479741